BIO 339M & 393

Spring 2007

Dr. Rasika Harshey

TTh 2 - 3.30 PM, RLM 7.114

Office Hours:

By appointment at NMS 2.118

Phone Number:

471-6881

Email:

rasika@uts.cc.utexas.edu

 

*  Syllabus                 Groups

You are responsible for printing online articles. I suggest you either download the PDFs on your laptops or e-mail them to yourself while on campus, since you may not be able to access many of the links from elsewhere.

 
* Topics

Jan 15            Overview of chemotaxis 

Jan 17            Discovery of chemoreceptors

Jan 22         Discovery of flagellar rotation      Group 1

Jan 24             Gradient sensing and chemotaxis     Group 2

Jan 29             Transmembrane signaling in a chemoreceptor      Group 3      

Jan 31              No class - see viewing assignment       

Feb 5              Signaling through a dimer        Group 4

Feb 7              Cytoplasmic signaling pathway: CheA        Group 5 

Feb 12            Regulation by phosphorylation: CheB         Group 6   

Feb 14            Regulation by phosphorylation: CheY          Group 7

Feb 19             Review        

Feb 21               Test 1             

                   From now on, you are responsible for initiating questions, and class participation will be graded accordingly.                     

Feb 26              Chemoreceptor clustering                                             

Feb 28              Trimer-of-dimers   

Mar 4               Clustering & Adaptation   

Mar 6               Morphogenetic signals: Flagella assembly           

 

SPRING BREAK

 

Mar 18            Morphogenetic signals: Needle length control    (Christine)

Mar 20             Surface (?) signals: Swarming in Vibrio parahaemolyticus                                           

Mar 25                                           :Swarming in Salmonella 

Mar 27                                           :Twitching in Pseudomonas aeruginosa/Myxococcus xanthus                            

Apr 1                  Review                                                      

Apr 3                     Test 2                  

Apr 8               Signaling for gene expression    (Mingjuan)

Apr 10             Cell density signals: Quorum sensing   (Eric)

Apr 15                                             :Quorum sensing (Jaemin)

Apr 17                                             :Biofilms   (Brian)

Apr 22             c-di-GMP signal: Caulobacter development    (Ali)     

Apr 24             Vancomycin tolerance: antibiotic & peptide signals (Kristin)

Apr 29              Test 3   Key
*   Reading

Jan 15-Feb 14

Feb 26-Mar 27

 

Apr 8

Makino et al., 1996. DNA binding of PhoB and its interaction with RNA polymerase. J. Mol.Biol. 259:15-26. 

 

Apr 10

Review: Henke JM and Bassler BL. Bacterial social engagements. Trends Cell Biol. 2004 14 :648-656.

 

Sandoz et al 2007. Social cheating in Pseudomonas aeruginosa quorum sensing. Proc Natl Acad Sci U S A. 104:15876-15881

 

Apr 15

1. Lenz et al., 2004. The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell 118:69-82

 

Apr 17

1. Mini-review: Kolter & Greenberg.  2006. Microbial sciences: the superficial life of microbes. Nature. 441:300-302.

2. Davies et al. 1998. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science. 280: 295-298.

 

Apr 22

Paul et al. 2004. Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes Dev. 18:715-27.

 

 

Apr 24

1. Novak et al. 1999. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature 399: 590-593.

2. Novak et al. 2000. Signal transduction by a death signal peptide. Mol. Cell 5: 49-57.

 

 

      

 
 

 

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