ELIZABETH WYCKOFF

EDUCATION:

B.A. (Biology), University of Oregon, Dept. of Biology, 1974
Ph.D. (Cellular, Viral, and Molecular Biology), University of Utah, Dept. of Cellular, Viral, and Molecular Biology, 1984

 

RESEARCH INTERESTS:

Lab mom!

I am interested in the mechanisms used by pathogenic bacteria to acquire iron with specific emphasis on the transport and utilization of heme.  Most of my work is with the gram negative pathogen Vibrio cholerae.

PUBLICATIONS:

Mey, A. R., E. E. Wyckoff, V. Kanukurthy, C. R. Fisher, and S. M. Payne. 2005. Iron and Fur regulation in Vibrio cholerae and the role of Fur in virulence. Infect. Immun. 73:8167-8178. (Abstract)

Wyckoff EE, Lopreato GF, Tipton KA, Payne SM. Shigella dysenteriae ShuS promotes utilization of heme as an iron source and protects against heme toxicity. (2005) J. Bacteriol. 187(16): 5658-5664. (Abstract)

Wyckoff EE, Schmitt M, Wilks A, Payne SM. (2004) HutZ is required for efficient heme utilization in Vibrio cholerae. J Bacteriol. 186(13):4142-4151.(Abstract)

Mey, A. R., E. E. Wyckoff, A. Oglesby, E. Rab, R. K. Taylor, and S. M. Payne. 2002. Identification of the Vibrio cholerae enterobactin receptors VctA and IrgA: IrgA is not required for virulence. Infect. Immun. 70:3419-3426.(Abstract)

Wyckoff, E.E., S.L. Smith, and S. M. Payne. 2001. VibD and VibH Are Required for Late Steps in Vibriobactin Biosynthesis in Vibrio cholerae. J. Bacteriol. 183(5):1830-1834. (Abstract)

Henderson, D. P., E. E. Wyckoff, C. E. Rashidi, H. Verlei, and A. L. Oldham. 2001. Characterization of the Plesiomonas shigelloides genes encoding the utilization of iron from heme. J. Bacteriol. 183:2715-2723. (Abstract)

Wyckoff, E.E., A. M. Valle, S. L. Smith, and S. M. Payne. 1999. A multifunctional ATP-binding cassette transporter system from Vibrio cholerae transports vibriobactin and enterobactin. Journal of Bacteriology 181(24):7588-96. (Abstract)

Hong, M., Gleason, Y., Wyckoff, E.E. and S.M. Payne. 1998. Identification of Two Shigella flexneri Chromosomal Loci Involved in Intercellular Spreading. Infection and Immunity. 66(10):4700-4710.(Abstract)

Occhino, D.A., Wyckoff, E.E., Henderson, D.P., Wrona, T.J., and S.M. Payne. 1998.Vibrio cholerae Iron Transport: Haem Transport Genes are Linked to One of Two Sets of tonB, exbB, exbD Genes. Molecular Microbiology. 29(6):1493-1507.(Abstract)

Wyckoff, E.E., Duncan, D., Torres, A.G., Mills, M., Maase, K. and S.M. Payne, 1998. Structure of the Shigella dysenteriae haem transport locus and its phylogenetic distribution in enteric bacteria. Molecular Microbiology. 28(6):1139-1152.(Abstract)

Wyckoff, E.E., Stoebner, J.A, Reed, K.E., and S. M. Payne. 1997. Cloning of a Vibrio cholerae vibriobactin gene cluster: Identification of genes required for early steps in siderophore biosynthesis. Journal of Bacteriology. 179(22):7055-7062.(Abstract)

Thomas, P.W., Wyckoff, E.E., Pishko, E.J., Yu, J.J., Kirkland, T.N., Cole, G.T. 1997. The hsp60 gene of the human pathogenic fungus Coccidioides immitis encodes a T-cell reactive protein. Gene. 199(1-2):83-91. (Abstract)

Wyckoff, E.E., Phillips, J.D., Sowa, A.M., Franklin, M.R., Kushner, J.P. 1996. Mutational analysis of human uroporphyrinogen decarboxylase. Biochim Biophys Acta. 1298(2):294-304. (Abstract)

Wyckoff, E.E., Pishko, E.J., Kirkland, T.N., Cole, G.T. 1995. Cloning and expression of a gene encoding a T-cell reactive protein from Coccidioides immitis: homology to 4-hydroxyphenylpyruvate dioxygenase and the mammalian F antigen. Gene. 161(1):107-111. (Abstract)

Wyckoff, E.E., Lloyd, R.E., Ehrenfeld, E. 1992. Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity. Journal of Virology.66(5):2943-2951. (Abstract)

Casjens, S., E. Wyckoff, M. Hayden, L. Sampson, K. Eppler, S. Randall, E. T. Moreno, and P. Serwer. 1992. Bacteriophage P22 portal protein is part of the gauge that regulates packing density of intravirion DNA. J. Mol. Biol. 224:1055-1074. (Abstract)

Casjens, S., K. Eppler, L. Sampson, R. Parr, and E. Wyckoff. 1991. Fine structure genetic and physical map of the gene 3 to 10 region of the bacteriophage P22 chromosome. Genetics 127:637-647. (Abstract)

Alvey, J.C., Wyckoff, E.E., Yu, S.F., Lloyd, R., Ehrenfeld, E. 1991. cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli. Journal of Virology. 65(11):6077-6083. (Abstract)

Eppler, K., E. Wyckoff, J. Goates, R. Parr, and S. Casjens. 1991. Nucleotide sequence of the bacteriophage P22 genes required for DNA packaging. Virology 183:519-538. (Abstract)

Wyckoff, E.E., Hershey, J.W., Ehrenfeld, E. 1990. Eukaryotic initiation factor 3 is required for poliovirus 2A protease-induced cleavage of the p220 component of eukaryotic initiation factor 4F. Proceedings of the National Academy of Sciences U.S.A. 87(24):9529-9533.  (Abstract)

Wyckoff, E.E., Croall, D.E., Ehrenfeld, E. 1990. The p220 component of eukaryotic initiation factor 4F is a substrate for multiple calcium-dependent enzymes. Biochemistry. 29(43):10055-10061. (Abstract)

Wyckoff, E., D. Natalie, J. M. Nolan, M. Lee, and T.-s. Hsieh. 1989. Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II. J. Mol. Biol. 205:1-13. (Abstract) 

Wyckoff, E., and T.-s. Hsieh. 1988. Functional expression of a Drosophila gene in yeast: genetic complementation of DNA topoisomerase II. Proc. Natl. Acad. Sci. USA 85:6272-6276. (Abstract)

Wyckoff, E., L. Sampson, M. Hayden, R. Parr, W. M. Huang, and S. Casjens. 1986. Plasmid vectors useful in the study of translation initiation signals. Gene 43:281-286. (Abstract)

Nolan, J. M., M. P. Lee, E. Wyckoff, and T.-s. Hsieh. 1986. Isolation and characterization of the gene encoding Drosophila DNA topoisomerase II. Proc. Natl. Acad. Sci. USA 83:3664-3668. (Abstract)

Wyckoff, E., and S. Casjens. 1985. Autoregulation of the bacteriophage P22 scaffolding protein gene. J. Virol. 53:192-197. (Abstract)

EMAIL ADDRESS: ewyckoff@mail.utexas.edu