|
BIO 329 (51395) Syllabus Spring 2007 |
(click on the headings below to jump to that heading)
Course
| Prerequisites | Instructor
| Text | Description
Grading
and Test Policy |
Tentative Class Schedule | Exam Schedule
| Class
Notes
 |
For
best results in printing, download
the PDF version of the syllabus by clicking on
the PDF icon to the left. |
|
|
| Course: |
BIO
329, 51395, Medical Mycology,
BUR 112, TTH 9:300-11:00 AM |
|
Prerequisites: |
Biology
325,325H and 226R with a grade of at least a C
in each.
Concurrent or subsequent enrollment in BIO 129L (Medical Mycology
Laboratory) is recommended for Medical Technology/Clinical
Laboratory Sciences majors. |
| Instructor: |
Dr. Paul J.
Szaniszlo: E-mail:
pjszaniszlo@mail.utexas.edu
(Office Hours: Mon 11:30 AM-12:30 PM, or by appointment in NMS
2.314)
|
| T.A.: |
Samantha
Croft: E-mail:
sbcroft@hotmail.com
(Office
Hour: MBB 2.424B,T from 11;00 AM-12:00 PM, or by
appointment in MBB 2.424B.
Discussion and Test Review Sessions will be held on
Tuesday 5-6,Wednesday 4:30-5:30 in Purlin 206 starting 1/30/07. These
sessions are optional, although quizzes may be
given and up to 5 bonus points/exam period can be
earned during these sessions. If you can not
attend any of these sessions, then please let
Samantha know your reasons and why you cannot
rearrange your schedule, in writing, before the 12th
class day (the syllabus for the Discussion
Sessions is presented below and she also has a
Discussion Section Quiz Website, which is
https://webspace.utexas.edu/sbc/www/ ). She will
then try to accommodate you. However, if she can't, and
you think you will need those potential points to
pass, then you should seriously consider dropping
this course.
|
Text:
(optional) |
Dismukes,
Pappus and Sobel. 2004. Clinical
Mycology, Oxford University Press, N. Y.
|
Readings:
(required) |
In addition, or as an alternative to the text
assignments, a number of articles will
be assigned throughout the course.
These readings are required and will be
available in the Life Sciences Library as one set of uncatalogued articles.
These readings can also be purchased at
Speedway Copy and Printing, in Dobie Mall, should
you want personal copies. The titles, authors, and sources of these
readings are listed below in the general
order they will be assigned.
|
|
Course Description: |
This
course consists of a basic introduction to medical
mycology and a comprehensive study of the yeasts,
molds and mycoses (fungal diseases) likely to
be encountered in clinical settings by a physician,
medical mycologist, or medical technologist.
Attention will be distributed as equally as
possible between emphasis on the fungal zoopathogen
and on its disease.
A general course outline in the form of a
Tentative Lecture Schedule (see below) is attached, as
well as a short Reserve Book List (see below).
|
|
Grading and Test Policy: |
There will be three semester examinations and an
optional comprehensive final.
The semester exams will focus on the material
covered since the last examination but the second
and
third exams will all require good
knowledge of prior coverage, and particularly the
material covered for the first examination.
Each examination will count equally
(33.3%), if you opt not to take the comprehensive
final.
Should you decide to take the final, it too will
count 33.3% and your lowest semester exam grade
will be dropped from the calculation for your
final average (Note: if you opt to take the
final, then it will be one of the three scores
used to calculate your final grade). Final averages will generally not be
curved, but instead most likely will be assigned
as follows:
85-100%
=
A
70-84%
=
B
55-69%
=
C
50-54%
=
D
and
less than 50%
=
F
|
|
PJS's Grading Philosophy: |
"Students earn grades, they are not given
grades." |
|
Examination Schedule: |
The three semester exams will be scheduled during
the regular class period, but in a
different room (ETC 2.108).
There will be no make-up exams unless there
is a substantial legitimate and documented,
significant
medical excuse or a documented
personal tragedy associated with your absence from
an examination.
Failure to take an examination may result
in a zero grade for that exam.
The date each exam will be given and the
approximate materials to be covered by each
are included in the
Tentative
2007 Schedule (see below). Should
this schedule not be acceptable then you should
consider dropping the course as soon as possible.
|
|
Class
Notes Packet: |
A
class notes packet will be available for your purchase at Speedway Copy and
Printing, Dobie Mall.
These notes will also be available at this
class web site, and in general represent only duplicated and
reformatted versions of the computer-generated
overheads prepared specifically for Bio 329 from
last year's Notes and only a few of the tables, but
not of any figures, diagrams or other
items to be presented similarly, as handouts or
possibly at this web-site.
The purchase of these items is totally at
your discretion and are provided only for
your note-taking convenience, so
you don't have to download from the web site, and can more easily take notes, make drawings, or
make records of additional materials (information
in tables, figures or graphs, for example) related to
lecture information that is not included in these
notes and which is strongly encouraged to be
studied.
|
|
Class Web Site: |
To help you keep up with things in BIO 329, there is
a class web-site associated with Medical Mycology.
Unless you are informed otherwise, the URL for this
site will be
http://www.sbs.utexas.edu/mycology/bio329/. |
|
Discussion Section
Syllabus |
Discussion sessions
are voluntary and will be held twice a week and are
designed to allow the students to ask questions
about difficult subject matter from the lectures.
Quizzes will be given weekly, which thoroughly cover
the previous week’s lecture materials. After
reviewing the quiz questions, students will be
allowed to ask questions and discuss unclear
concepts. I will also point out material which
students have struggled with in the past and give
study tips. The discussions before the exam will be
review sessions where I will give an overview of the
lecture material covered for that exam and answer
questions.
Bonus Points:
During the two voluntary discussion sessions,
quizzes will be given to allow students to earn up
to 5 bonus points per exam. Each week a quiz worth
5 points will be given and students may take all
three quizzes per exam (ONLY one per week), but only
the highest quiz score will be applied to their
exam.
Attendance: If
a student cannot attend either the discussion
sessions or the office hours listed below, they must
contact me in writing by the twelfth class day with
the reason for the scheduling conflict so that other
arrangements can be made. If I am not contacted by
this time, I will assume that the student is able to
attend one of the allotted times and failure to
attend is voluntary. If a scheduling conflict arises
mid semester, it is the student’s responsibility to
contact me immediately. I will not allow make-up
quizzes as there are multiple opportunities per exam
for the students to earn points, with exceptions
only for serious illness that has caused absence for
several weeks.
Discussion sessions: Tuesdays at 5-6 PM
and Wednesdays at 4:30-5:30 PM in (site to yet be
arranged).
Office Hours: Tuesdays 11:00 AM- 12:00 PM or
by appointment in (MBB
2.424B)
|
|
(Back
to top of page) |
|
| Tentative
Spring 2007
Lecture Schedule - BIO 329 |
|
JAN |
16 |
Course
Introduction (and start) |
| |
18 |
General
Introduction to Medical Mycology |
| |
23 |
Definitions
and Fungal Terminology |
| |
25 |
Fungal Classification |
|
|
30 |
Concepts
of Anamorphy, Teleomorphy, Holomorphy and Fungi
Imperfecti
|
|
FEB |
1 |
Conidia
and Other Spores |
|
|
6 |
General
Aspects of Fungal Immunology and Pathology |
| |
8 |
Antifungal
Therapeutic Agents |
| |
13 |
Antifungal
Therapeutic Agents |
| |
15 |
The
Superficial Mycoses |
|
FEB |
20 |
EXAM
I
- In ETC 2.108, coverage through antifungals |
| |
22 |
Dermatophytosis and the
Dermatophytes |
| |
27 |
Dermatophytosis
and the Dermatophytes |
|
MAR |
1 |
Introduction to Subcutaneous Mycoses, with emphasis on
those caused by dematiaceous (black) fungi |
| |
6 |
Chromoblastomycosis |
| |
8 |
Phaeohyphomycosis,
Mycetoma, Other Diseases Caused by Black Fungi
|
|
MAR |
12-16 |
SPRING
BREAK |
| |
20 |
Sporotrichosis
|
| |
22 |
Introduction
to the Pathogenic Yeasts
|
| |
27 |
Candidiasis |
|
|
29 |
Candidiasis and Cryptococcosis |
|
APR |
3 |
Cryptococcosis |
|
APR |
5 |
EXAM
II
- In ETC2.108, coverage through candidiasis |
| |
10 |
Histoplasmosis |
| |
12 |
Blastomycosis |
| |
17 |
Coccidiodomycosis |
| |
19 |
Coccidiodomycosis |
|
APR |
24 |
Aspergillosis |
|
APR |
26 |
EXAM
III - In ETC 2.108, coverage through
aspergillosis |
|
MAY |
1 |
Fungal Allergies
and
Mushrooms |
| |
4 |
Mushroom Poisonings,
mycotoxins and Finishing Up |
|
MAY |
12 |
Optional
Comprehensive Final Examination (see grading and test
policies on page 1 for details). |
|
(Back
to top of page) |
|
|
Reading
List
- BIO 329 |
|
|
For
best results in printing, download
the PDF version of the syllabus by clicking on
the PDF icon to the left. |
|
RESERVE
BOOK LIST - Spring 2007- Paul J. Szaniszlo
These
books are on reserve in the Life Science Library and
should be of help should you need supplemental reading
on certain topics introduced in Bio 329. |
|
|
|
Medical Mycology |
|
Clinical Mycology, Dismukes, Papus
and Sobel |
|
QR 245, C566, 2003 |
|
Medical Mycology, Kwon-Chung and Bennett |
|
QR 245, K86, 1992 |
|
Atlas
of Clinical
Mycology, deHoog et al., |
|
QR 245, K86, 2000 |
|
Microbiology and Microbial Infections, Topley and
Wilson’s, 9th ed., Vol. 4. Medical
Mycology |
|
QR 46, T6, 1998 |
|
Molecular Principles of Fungal
Pathogenesis, Heitman et al. |
|
QR 245, M65, 2006 |
|
Dimorphic Fungi in Biology and Medicine,
Vanden Bossche, Odds and Kerridge (eds) |
|
QR 245, D55, 1993 |
|
Medical Mycology: A Practical Approach, Evans and
Richardson |
|
QR248, M43, 1989 |
|
Medical Mycology and Human Mycoses, Beneke and
Rogers
|
|
QR245, B46, 1996 |
|
Medical Mycology, 3rd ed., Rippon |
|
RC 117, R5, 1988 |
|
Fungal Dimorphism: With Emphasis on Fungi Pathogenic for
Humans, Szaniszlo |
|
QR 245, 1985 |
|
Laboratory Handbook of Medical Mycology, McGinnis |
|
RC 117, E56, 1980 |
|
Identifying Filamentous Fungi: a Clinical
Laboratory Handbook,
St-Germain and Summerbell |
|
QR 248, F55
|
|
Fungal Pathogenesis: Principles and
Clinical Applications, Calderone and Chilar, ed.
RC117, F864,
2000 |
|
General
Mycology |
|
Ainsworth & Bisby's Dictionary of the Fungi, 8th
ed., Hawksworth, Krik, Sutton & Pegler |
|
QK603, A5, 1995 |
|
Dictionary
of the Fungi, 9th ed., Hawksworth et al., |
|
QK 600.35, A5, 2001 |
|
The Fifth
Kingdom, 3rd
ed., Kendrick |
|
QK 603, K46, 1992 |
|
Introductory Mycology, 4th ed., Alexopoulos,
Blackwell and Mims |
|
QK 603, A55, 1996 |
|
Fundamentals of the Fungi, 4th ed., Moore-Landecker |
|
QK 603, M62, 1996 |
|
The Fungi, 2nd ed., Watkinson, Carlile
and Gooday |
|
QK 603, C257, 2001
|
|
BIO
329
- RESERVE READING LIST - SPRING 2007- PAUL J.
SZANISZLO
(In
Life Science Library as a set of
articles)
These
articles are also available through Speedway Copy and
Printing, Dobie Mall, and are required
readings. Although
you may not be tested directly on the content of these
articles, they will help you to better appreciate the
subjects and to write better essay discussions, if
requested.
|
| Sz |
1 |
Sternberg,
S. (1994) The
emerging fungal threat.
Science 226:1632-1634.
|
| Sz |
2 |
Perfect, J. R. 2005. Weird Fungi. ASM News
71:407-411. |
| Sz |
3 |
Mitchell, T. G. (1998) Medical mycological research
and training: needs and opportunities. ASM News
64:17-23. |
| Sz |
4 |
Kwon-Chung, K. J. and B. L. Wickes.
The conversion from classical studies in fungal
pathogenesis to the molecular era. In: Molecular
Principles of Fungal Pathogenesis, ASM Press, pp.
49-70. |
| Sz |
5 |
Mendoza, L., L. Ajello and J. W. Taylor (2001) The
taxonomic status of Lacazia loboi and
Rhinosporidium seeberi has been finally resolved
with the use of molecular tools. Rev. Iberoam. Micol.
18:95-98. |
| Sz |
6 |
Cushion, M. T. Pneumocystis:
Unraveling the cloak of obscurity. TIM 12:243-249. |
| Sz |
7 |
Taylor, J. W. 2006. Evolution of human-pathogenic
fungi: phylogenies and species. In: Molecular
Principles of Fungal Pathogenesis, ASM Press, pp.
113-131.
|
| Sz |
8 |
Casadevall, A. 2006. Cards of
virulence and the global virulome for humans. Microb,
ASM Press, 1:359-364. |
|
Sz |
9 |
Szaniszlo, P. J. (1985) An introduction to
dimorphism among zoopathogenic fungi. In: Fungal
dimorphism, with emphasis on fungi pathogenic for
humans. Chapter 1, pp. 3-13. |
| |
| Sz |
10 |
Romani, R. 2004. Immunity to fungal infections. Nature
Reviews: Immunology. 4:1-12. |
| Sz |
11 |
Odds, F. C., A. J. P. Brown, and N.
A. R. Gow. 2003. Antifungal agents : mechanisms of
action. TIM. 11:272-279. |
| Sz |
12 |
Kauffman, C. 2006. Clinical efficacy of new antifungal
agents.
Curr. Opin. Microbiol. 9:483-488. |
|
Sz |
13 |
Gueho, E., J. Faergemann, C. Lyman, and E. J. Anaissie.
(1994) Malassezia and Trichosporon: two
emerging pathogenic basidiomycetous yeast-like fungi.
J. Med. Vet. Mycol. Suppli. 32:367-378. |
| Sz |
14 |
Weitzman, I., and R. C. Summerbell. (1995) The
dermatophytes. Clin. Microbiol. Rev. 8:240-259. |
| Sz |
15 |
Kac,
G. (2000) Molecular approaches to the study of
dermatophytes. Med. Mycol. 38:329-336. |
| Sz |
16 |
Jacobson, E. S. (2000) Pathogenic roles for fungal
melanins. Clin. Microbiol. Rev. 13:708-717 |
| Sz |
17 |
Szaniszlo, P. J., L. Mendoza, and S. M. Karappayil.
(1993) Clues about chromoblastomycotic and other
dematiaceous pathogens based on Wangiella as a
model. In: Dimorphic fungi in biology and medicine.
pp. 241-255. |
| Sz |
18 |
Szaniszlo, P. J. (2002) Molecular
genetic studies of the model dematiaceous pathogen Wangiella
dermatitidis. Int. J. Med. Microbiol. 292:381-390. |
| Sz |
19 |
Brandt, M.
E. et al. (2000) Candida dubliniensis fungemia: the
first four cases in North America. Emerg.
Infect. Dis. 6:46-49 |
| Sz |
20 |
Pfaller, M. A., and D. J. Diekema.
2002. Role of sentinal surveiance of candidemia:
trends in species distribution and antifungal
susceptibility. J. Clin. Microbiol. 40:3551-3557. |
|
Sz |
21 |
Fidel, P. L. 2004. History and new
insights into host defenses against vaginal candidiasis.
TIM 12: 220-227. |
| Sz |
22 |
Hube, B. 2004. From commensal to
pathogen: stage- and tissue-specific gene expression
of Candida albicans. Curr. Opin. Microbiol.
7:336-341. |
| Sz |
23 |
Sudbury, P., N. Gow. and J. Burman.
2004. The distinct morphogenetic states of
Candida albicans.
12:317-324. |
| Sz |
24 |
Douglas, L. J. (2003) Candida
biofilms and their role in infection. TIM 11:30-36. |
| Sz |
25 |
Magee, P. T. and B. B. Magee. 2004.
Through a glass opaquely: the biological significance
of mating in Candida albicans. Curr. Opin. Microbiol. 7:661-665. |
| Sz |
26 |
Noverr, M. C., D. M. Lindell, G. B. Toews and G. B.
Huffnagel. 2006. Fungal interactions with leukocytes.
In: Molecular Principles of Fungal Pathogenesis, ASM
Press, pp. 555-563. |
| Sz |
27 |
McClelland, C. M., Y. C. Chang, A.
Varma and K.J. Kwon-Chung. 2004. Uniqueness of the
mating system in
Cryptococcus neoformans.
TIM 12:208-212. |
| Sz |
28 |
Feldmesser, M., S. Tucker and A. Casadevall. (2001)
Intracellular parasitism of macrophages by Cryptococcus neoformans. TIM
9:273-278; and related TIM
letters 9:417-418.. |
| Sz |
29 |
Doering, T. L. (2000) How does Cryptococcus get its coat? TIM 12:547-553; and
related (2001) TIM letters 9:112-113. |
| Sz |
30 |
Woods, J. P. (2003) knocking on the
right door and making a comfortable home:
Histoplasma capsulatum inttracellular pathogenisis.
Curr. Opin. Microbiol. 6:327-331. |
| Sz |
31 |
Ignatov, A., and E. J. Keath (2002)
Molecular cell biology and molecular genetics of
Histoplasma capsulatum. Int. J. Med. Microbiol.
292:349-361. |
| Sz |
32 |
Brandhorst, T.T., P. J. Rooney, T. D. Sullivan, and B.
S. Klien (2002) Molecular genetic analysis of Blastomyces
dermatitidis reveals new insights about pathogenic
mechanisms. Int. J. Med.Microbiol. 292: 363-371. |
| Sz |
33 |
Kirkland,
T. N., and J. Frierer. (1996) Coccidioidomycosis: a
reemerging infectious disease. Emerg. Infect. Dis.
2:192-199. |
| Sz |
34 |
Abuodeh, R. O., J. N. Galgiani, and
G. M. Scaralone. (2002) Molecular approaches to the
study of Coccidioides immitis. Int. J. Med.
Microbiol. 292:373-380. |
| Sz |
35 |
Latgé, J-P. (2001) The pathobiology of
Aspergillus fumigatus. TIM
9:382-389. |
| Sz |
36 |
Tekaia, F, and J-P. Latgé. 2005.
Aspergillus fumigatus: saprophyte or pathogen?
Curr. Opin. Microbiol.
8:385-392. |
| Sz |
37 |
Andrianopoulos, A. (2002) Control
of morphogenesis in the human fungal pathogen Penicillium
marneffei. Int. J. Med. Microbiol. 292: 331-347. |
| Sz |
38 |
McGinnis, M. R. 2004. Pathogenesis of indoor fungal
diseases. Medical Mycology. 42:107-117. |
|
(Back
to top of page) |
|
|
