JAYARAM LAB

Home

Projects

Landmarks

Publications

People

Protocols

Awards

Research Supports

Gallery

Supplements

Contact

Projects

How do “benign” parasite genomes coexist with host genomes without overburdening the latter's metabolic potential?

To answer this question, we examine how an extrachromosomal element in yeast, the 2 micron plasmid, has optimized its copy number and its segregation mechanism for stable propagation.

The individual projects are:

1. Plasmid partitioning during cell division

2. Plasmid copy number control

3. Mechanisms of site-specific DNA recombination

4. Applications of site-specific recombination

(A) in biotechnology and genetic engineering

(B) in basic biology using topological methods

From the global perspective of genome interactions, we would like to know how the partitioning and amplification systems communicate with each other, and how each one is regulated to ensure the stable persistence of the yeast plasmid.