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Welcome to the Vokes Lab at the University of Texas at Austin. Our major research interests lie in understanding the transcriptional and cis-regulatory mechanisms underlying Hedgehog signaling during embryonic development and cancer. Our experimental approach is centered on the developing mouse limb bud, where we employ a combination of genetic, molecular and genomic approaches. Click here for a detailed description.
Our current efforts are focused on two major questions:
How do transcription factors mediate Hedgehog signaling?
How are multiple signaling pathways integrated at the transcriptional level?
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