Grad Student AccomplishmentsRecent Publications
M. D. Lazova, M. T. Butler, T. S. Shimizu and R. M. Harshey. 2012. Salmonella chemoreceptors McpB and McpC mediate a repellent response to L-cystine: a potential mechanism to avoid oxidative conditions. Mol. Microbiol.
J. Lee and R. M. Harhey. 2012. Loss of FlhE in the flagellar Type III secretion system allows proton influx into Salmonella and Escherichia coli. Mol. Microbiol. 84:550-565.
A. Be’er and R. M. Harshey. 2011. Collective motion of surfactant-producing bacteria imparts superdiffusivity to their upper surface. Biophys J. 101:1017-24.
K. Paul. V. Nieto, W. C. Carliquist, D. F. Blair and R. M. Harshey. 2010. The c-di-GMP-binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a ‘backstop break’ mechanism. Mol. Cell. 38: 128–139.
Commentary in: Cell Apr 2, 2010 141:24-26.
M. Butler, Q. Wang and R. M. Harshey. 2010. Cell density and mobility protect swarming bacteria against antibiotics. Proc. Natl. Acad. Sci. USA. 107:3776–3781.
Q. Wang and R. M. Harshey. 2009. Rcs signaling-activated transcription of rcsA induces strong anti-sense transcription of upstream fliPQR flagellar genes from a weak intergenic promoter: regulatory roles for the anti-sense transcript in virulence and motility. Mol. Microbiol. 74: 71-84.
U. Attmannspacher, B. Scharf and R. M. Harshey. 2008. FliL is essential for swarming: motor rotation in absence of FliL fractures the flagellar rod in swarmer cells of Salmonella enterica. Mol. Microbiol. 68: 328-341.
Q. Wang, Y. Zhao, M. McClelland and R. M. Harshey. 2007. The RcsCDB signaling system and swarming motility in Salmonella enterica serovar Typhimurium: dual regulation of flagellar and SPI-2 virulence genes. J. Bacteriol. 189: 8447-8457.
Q. Wang, S. Mariconda, A. Suzuki, M. McClelland and R. M. Harshey. 2006. Uncovering a large set of genes that affect surface motility in Salmonella enterica serovar Typhimurium. J. Bacteriol. 188: 7981-7984.
Selected Other Publications
S. Mariconda, Q. Wang and R. M. Harshey. 2006. A mechanical role for the chemotaxis system in swarming motility. Mol. Micro. 60: 1590-1602.
Q. Wang, A. Matsuura, S. Mariconda, S. Porwollik and R. M. Harshey. 2005. Sensing wetness: A new role for the bacterial flagelllum. EMBO J. 24: 2034–2042.
Commentary in:
Nature, 26, May 2005, 435: 388.
Science, 20 May 2005, 308: 1089.
EMBO Reports, June 2005, 6: 518-519.
Current Biology, Aug 2005, 15:R599-600
Faculty of 1000: Victor Norris: http://www.f1000biology.com/article/15889148/evaluation
Q. Wang, J. G. Frye, M. McClelland and R. M. Harshey. 2004. Gene expression patterns during swarming in Salmonella typhimurium: genes specific to surface growth and putative new motility and pathogenicity genes. Mol. Microbiol. 52: 169-187.
R. M. Harshey. 2003. Bacterial motility on a surface: many ways to a common goal. Ann. Rev. Microbiol. 57: 249-273.
J. R. Mireles II, A. Toguchi and R. M. Harshey. 2001. Salmonella enterica swarming mutants with altered biofilm forming abilities: surfactin inhibits biofilm formation. J. Bacteriol. 314: 5848-5854.
A. Toguchi, M. Siano, M. Burkart and R. M. Harshey. 2000. Genetics of swarming motility in Salmonella enterica Serovar Typhimurium: Critical role for lipopolysaccharide. J. Bacteriol. 182: 6308-6321.
M. Burkart, A. Toguchi and R. M. Harshey. 1998. The
chemotaxis system, but not chemotaxis, is essential for swarming motility in E.
coli.
Proc. Natl. Acad. Sci. USA,
95: 2568-2573.
T. Matsuyama, A. Bhasin and R. M. Harshey. 1995. Mutational analysis of flagellum-independent surface spreading of Serratia marcescens 274 on low-agar medium. J. Bacteriol. 177: 987-991.
R. M. Harshey. 1994. Bees aren't the only ones : Swarming in Gram-negative bacteria. Mol. Microbiol. 13: 389-394.
R. M. Harshey and T. Matsuyama. 1994. Dimorphic transition in E. coli and S. typhimurium: Surface-induced differentiation into hyperflagellate swarmer cells. Proc. Natl. Acad. Sci. USA, 91: 8631-8635.
L. Alberti and R. M. Harshey. 1990. Differentiation of Serratia marcesens 274 into swimmer and swarmer cells. J. Bacteriol. 172:4322-4328.
Funding