Amanda Oglesby
Mandy and Harley
EDUCATION:
Ph.D. (Microbiology)
University of Texas. 2005
B.S. (Microbiology) University of Texas, 2000
RESEARCH INTERESTS:
Shigella, the causative agent of bacillary dysentery, is exquisitely adapted to surviving acidic environments. Studies in other bacteria have indicated a link between survival in acidic environments and the Fur regulatory protein. Fur (ferric uptake regulator), an iron-binding protein, mediates iron homeostasis inside the cell. Fur has also been shown to regulate genes involved in other cellular processes and may play a more global regulatory role. Microarray analysis of wild type and Fur- Shigella flexneri was used previously to identify genes that mediate iron acquisition. The data obtained also indicated an induction of genes involved in the acid response in the fur mutant. My research currently is focused on studying the link between Fur and acid response in S. flexneri.
PUBLICATIONS / ABSTRACTS:
Payne SM, Wyckoff EE, Murphy ER, Oglesby AG, Boulette M, and Davies N. 2006. Iron and pathogenesis of Shigella: iron acquisition in the intracellular environment. Biometals. 19:173-180.
Oglesby AG, Murphy ER, Iyer VR, Payne SM. 2005. Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP. Mol. Microbiol. 58:1354-1367.
Oglesby AG and Payne SM. 2005. RyhB represses glutamate-independent acid resistance in Shigella flexneri. 105th ASM General Meeting.
Oglesby AG, Murphy ER, and Payne SM. 2004. Fur-mediated iron regulation is required for Shigella flexneri acid resistance. 104th ASM General Meeting.
Oglesby AG, Murphy ER, Reus BE, Davies JL, Iyer VR, Payne SM. 2003. Microarray Analysis of Iron-Regulated Gene Expression in Shigella flexneri. 103rd ASM General Meeting.
Mey AR, Wyckoff EE, Oglesby AG, Rab E, Taylor RK, Payne SM. 2002. Vibrio cholerae IrgA is a receptor for enterobactin. 102nd ASM General Meeting.
Mey AR, Wyckoff EE, Oglesby AG, Rab E, Taylor RK, Payne SM. 2002.
Identification of the Vibrio cholerae Enterobactin Receptors VctA and
IrgA: IrgA Is Not Required for Virulence. Infect. Immun. 70:3419-3426. (Abstract)
EMAIL ADDRESS: Amanda.Oglesby@UCHSC.edu
