Histoplasmosis and Ajellomyces (Histoplasma) capsulatum

  Histoplasma capsulatum and Ajellomyces casulatus:  in vitro
       
       
  Holoblastic macroconidia at 25°C   Hypha and tuberculate macroconidia   Yeast cells at 37°C  
             
           
  Typical older white mold colony at 25°C
Older = after many subcultures		          
             
   

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  H. capsulatum:  In tissue  
       
       
  In liver          
             
       
          mΦ with many yeast cells from acute pulmonary case  
             
           
  H + E; yeast cells in phagocyte yeast cell shrunk from cell wall looks like a capsule          
             
   

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  Histoplasmosis:   Residual lesions  
       
       
      Residual calcified lesions in lung   Lesions (calcified) in spleen from previous acute histoplasmosis (0.2-0.4 cm in diameter)  
             
   

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  Cutaneous lesions:  
       
       
  From dissemination   From dissemination   From dissemination  
             
           
  Primary lesion from lab accident          
             
   

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