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Dematiaceal & Subcutaneous Mycoses

Dematiaceae / Chromoblastomycosis / Sclerotic bodies /

Phaeohyphomycosis by W. dermatitidis / Phaeohyphomycosis by E. spinifera /

Cladosporiosis / Eumycotic Mycetoma: black and white grains /

	Dematiaceae: Selected Dematiaceae that are medically important (the dematiaceous pathogens)


	Piedraia hortae of black piedra		Exophiala werneckii of tinea nigra


	Phialophora verrucosa, Fonsecaea pedrosoi, and F. compacta of chromoblastomycosis		Wangiella/Exophiala dermatitidis of phaeohyphomycosis


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	Chromoblastomycosis:


	Pedunculated verrucous lesions resembling florets of cauliflower		Pedunculated verrucous lesions resembling florets of cauliflower		Old chronic disease with some scarring and keloid formation. Many lesions were inactive


	Active marginal lesion with inactive center		Chronic verrucous infection of foot with secondary infection leading to elephantiasis.		Chest lesion with healing atrophic scarring center and an active raised border is present


	P. verrucosa		F. pedrosoi		C. corrionii


	Enteroblastic P. vurrucosa		Holoblastic botryose conidia (sympodulo-conidia)		Holoblastic conidia (catenulate)


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	Sclerotic bodies: of Chromoblastoycosis fungi


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	Phaeohyphomycosis: caused by Wangiella/Exophiala dermatitidis


	Toenail and facial lesions		In vivo phenotypes		Colony on rich medium


	Scanning of yeast cells		A. hyphae, conrdiophores and conidia, B. normal sized yeasts, C. enlarged yeasts, D. multicellular (sclerotic-like) forms		Multicellular forms exhibiting fissions


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	Phaeohyphomycosis: caused by Exophiala spinifera

	4/1984 8/1984 4/1985
	Intraconazol treatment		E. spinifera in vivo


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	Cladosporiosis:


	In vitro blastoconidia		In vivo from lesion aspirate		Cerebral lesion with fungal mass and missing area due to necrosis


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	Eumycotic Mycetoma: Black and white grain


	Madura foot		Madura foot		Madura foot


	Draining lesions on arms		Draining lesions on arm		Draining lesions on torso

	Black grains in tissue by dematiaceus fungi:


	Exophiala jeanselmei		Curvularia lunata		C. geniculata


	C. geniculata


	White grain in tissue and mycotic keratitis by Pseudoallesheria boydii:


	Pseudallescheria boydii		Scedosporium prolificans		Grains stained by acetocarmine


	Grains stained by immunofluorecent		Eye infection		Systemic infection


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	Sporotrichosis: By Sporothrix schenckii

	Lymphocutaneous sporotrichosis:


	Initial lesion is discolored, ulcerated and draining, secondary lesions are elevated, but not ulcerated.		Lympho-cutaneous		Non-ulcerating lesions on arm


	Gummatous lesions on arm

	Cutaneous & subcutaneous sporotrichosis in tissue sections:


	Cutaneous lesions		Numerous small micro abscesses in liver (rare systemic form; hematoxylin and lesion)		Tuberculoid granuloma type lesion. Hematoxylin and eosin stain


	Giant cells, fibroblasts, and lymphocytes. Hematoxylin and eosin stain

	Fixed cutaneous sporotrichosis:


	Laboratory acquired primary lesion		Advanced fixed lesion		Ulcerating fixed lesion and satellite


	Finger and satellite "nodule"		Facial lesions and satellites		Facial lesions and culture

	Sprorthrix schenckii in vivo tissue forms in sporotrichosis:


	Yeast forms in cutaneous disease		Yeast forms in cutaneous disease


	Asteroid bodies in cutaneous disease		Asteroid bodies in cutaneous disease

	Sporothrix schenckii in vetro:


	Dematiaceous macroconidia		"Roping" hyphae and holoblastic botryose conidia		Yeast cells at 37°C


	Left) Folded brown tan mold colony at 25°C; Right) White pasty yeast colony at 37°C


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For questions, comments, or suggestions, please send e-mail to: sher-lu@mail.utexas.edu	The University of Texas at Austin