Dematiaceal & Subcutaneous Mycoses

Dematiaceae / Chromoblastomycosis / Sclerotic bodies /

Phaeohyphomycosis by W. dermatitidis / Phaeohyphomycosis by E. spinifera /

Cladosporiosis / Eumycotic Mycetoma: black and white grains /

  Dematiaceae:  Selected Dematiaceae that are medically important (the dematiaceous pathogens)  
     
     
  Piedraia hortae of black piedra   Exophiala werneckii of tinea nigra  
         
     
  Phialophora verrucosa, Fonsecaea pedrosoi, and F. compacta of chromoblastomycosis   Wangiella/Exophiala dermatitidis of phaeohyphomycosis  
         
   

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  Chromoblastomycosis:    
       
       
  Pedunculated verrucous lesions resembling florets of cauliflower   Pedunculated verrucous lesions resembling florets of cauliflower   Old chronic disease with some scarring and keloid formation.  Many lesions were inactive  
             
       
  Active marginal lesion with inactive center   Chronic verrucous infection of foot with secondary infection leading to elephantiasis.   Chest lesion with healing atrophic scarring center and an active raised border is present  
             
       
  P. verrucosa   F. pedrosoi   C. corrionii  
             
       
  Enteroblastic        P. vurrucosa   Holoblastic botryose conidia (sympodulo-conidia)   Holoblastic conidia (catenulate)  
         
   

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  Sclerotic bodies: of Chromoblastoycosis fungi  
       
       
             
           
         
   

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  Phaeohyphomycosis: caused by Wangiella/Exophiala dermatitidis  
       
  face-nail1thm.jpg (13321 bytes)      
  Toenail and facial lesions   In vivo phenotypes   Colony on rich medium  
             
       
  Scanning of yeast cells   A. hyphae, conrdiophores and conidia, B. normal sized yeasts, C. enlarged yeasts, D. multicellular (sclerotic-like) forms   Multicellular forms exhibiting fissions  
         
   

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  Phaeohyphomycosis: caused by Exophiala spinifera  
       
 

4/1984        8/1984      4/1985

   
  Intraconazol treatment   E. spinifera in vivo  
         
   

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  Cladosporiosis:    
       
       
  In vitro blastoconidia   In vivo from lesion aspirate   Cerebral lesion with fungal mass and missing area due to necrosis  
         
   

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  Eumycotic Mycetoma:  Black and white grain  
       
       
  Madura foot   Madura foot   Madura foot  
             
       
  Draining lesions on arms   Draining lesions on arm   Draining lesions on torso  
             
  Black grains in tissue by dematiaceus fungi:  
       
       
  Exophiala jeanselmei   Curvularia lunata   C. geniculata  
             
           
  C. geniculata          
       
  White grain in tissue and mycotic keratitis by Pseudoallesheria boydii:  
       
       
  Pseudallescheria boydii   Scedosporium prolificans   Grains stained by acetocarmine  
             
       
  Grains stained by immunofluorecent   Eye infection   Systemic infection  
             
         
   

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  Sporotrichosis:  By Sporothrix schenckii  
       
  Lymphocutaneous sporotrichosis:  
       
       
  Initial lesion is discolored, ulcerated and draining, secondary lesions are elevated, but not ulcerated.   Lympho-cutaneous   Non-ulcerating lesions on arm  
             
           
  Gummatous lesions on arm          
             
  Cutaneous & subcutaneous sporotrichosis in tissue sections:  
       
       
  Cutaneous lesions   Numerous small micro abscesses in liver (rare systemic form; hematoxylin and lesion)   Tuberculoid granuloma type lesion.  Hematoxylin and eosin stain  
             
           
  Giant cells, fibroblasts, and lymphocytes.  Hematoxylin and eosin stain          
             
  Fixed cutaneous sporotrichosis:  
       
       
  Laboratory acquired primary lesion   Advanced fixed lesion   Ulcerating fixed lesion and satellite  
             
       
  Finger and satellite "nodule"   Facial lesions and satellites   Facial lesions and culture  
             
  Sprorthrix schenckii in vivo tissue forms in sporotrichosis:  
       
     
  Yeast forms in cutaneous disease   Yeast forms in cutaneous disease  
         
     
  Asteroid bodies in cutaneous disease   Asteroid bodies in cutaneous disease  
         
  Sporothrix schenckii in vetro:  
       
       
  Dematiaceous macroconidia   "Roping" hyphae and holoblastic botryose conidia   Yeast cells at 37C  
             
           
  Left) Folded brown tan mold colony at 25C; Right) White pasty yeast colony at 37C          
             
         
   

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