TOPICS

1. DNA - The structure and chemistry of the genetic material
   
   1. DNA Structure, Chemistry
   2. A, B, Z DNA
   3. Discussion Points on ‘DNA Structure and Chemistry’
   4. Slide Show on DNA structure, Chemistry and Organization
   5.  DNA grooves
   6. Student queries and answers
   7. DNA Recognition
      
      
2. Duplicating Genetic Information-DNA Replication
   
   1. DNA Replication
   2. Discussion Points on ‘DNA Replication’
   3. Slide Show on DNA Replication; Slide Show on DNA Replication (Power Point)
   4. Animation: Replication Fork
   5. DnaA: Opening the Replication Fork
   6. Review-Coordination of replication and cell division
   7. Student queries and answers
      
      
3. DNA topology
   
   1. Concepts in DNA Topology
   2. Discussion Points on ‘DNA Topology
   3. Slide Show on DNA Topology
   4. Animation: Chromatin
   5. Review-ethidium bromide binding
   6. Student queries and answers
      
      
4. Exchange of Genetic Information: Homologous Recombination
   
   1. Homologous Genetic Recombination
   2. Models of Recombination
   3. Discussion Points on Recombination
   4. Slide Show on Recombination
   5. Animation: Homologous Recombination
   6. Animation: Meselson-Radding Model
   7. Animation: Double Strand Break Repair
   8. Animation: Recombination; RuvAB-branch migration
   9. Animation: Branch migration: Holliday junction resolution
   10. Student queries and answers
       
       
5. Site-specific DNA Recombination
   
   1. Site-specific Recombination: Mechanisms, Biological Consequences and Applications
   2. Discussion Points on Site-specific Recombination
   3. Slide Show on Site-specific Recombination
   4. Animation: VDJ Recombination
   5. Animation: VJ Recombination
   6. Student queries and answers
      
      
6. DNA Transposition
   1. Mobile DNA Elements: Mechanisms of DNA transposition
   2. Discussion Points on DNA Transposition
   3. More on V-D-J Recombination
   4. Student queries and answers
      
      
7. Original papers
   1. Paper I- Kitamura et al.
      A1. Paper I- Background
      A2. Paper I- Presentation
      A3. Paper I- Discussion Points
      A4. GFP-Living colors
      
      
   2. Paper II- Ghosh et al.
      B1. Paper II- Background
      B2. Paper II- Presentation
      B3. Paper II- Discussion Points
      
      
   3. Paper III- Pathania et al.
      C1. Paper III- Background
      C3. Geometry of Flp (or Cre) recombination
      C2. Paper III- Presentation
      C3. Discussion Points

Contact Info

Email: jayaram@iaustin.utexas.edu

Office Hours:

Wednesdays; 2.00-3.00 pm

NMS Building; Room 2.116

Important Dates

October 7, 2014